HCID 18368181, compound → HCID 18368172, compound

Participants

Reaction Steps

A mixture of 2-benzoyl-3-(3-benzyloxybutyrylamino)-6-chloroindole (Step 1) (2.3 g, 5.1 mmol) and 10% Pd—C (0.2 g) in ethyl acetate (50 ml) was stirred at room temperature for 24 h under a hydrogen atmosphere. The mixture was filtered through a pad of Celite and the filtrate was concentrated. Purification by flash column chromatography eluting with hexane/ethyl acetate (1/1) gave a yellow amorphous solid. Recrystallization from ethyl acetate/hexane afforded 290 mg (16%) of the titled compound as a pale yellow solid. m.p.: 159-162° C.

Provenance & Evidence