Isovaleryl chloride → 6-Chloro-2-(4-chloropyridine-2-carbonyl)-3-(isovalerylamino)indole

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 19 from 3-amino-6-chloro-2-(4-chloropyridine-2-carbonyl)indole (Example 68) and isovaleryl chloride. m.p.: 183-184° C. (recrystallized from ethyl acetate) 1H-NMR (DMSO-d6) δ: 11.67 (1 H, br s), 10.08 (1 H, br s), 8.69 (1 H, d, J=5.3 Hz), 8.52 (1 H, d, J=9.2 Hz), 8.37 (1 H, d, J=2.1 Hz), 7.57 (1 H, dd, J=2.0, 5.3 Hz), 7.39 (1 H, d, J=2.0 Hz), 7.06 (1 H, dd, J=2.0, 9.6 Hz), 2.46-2.30 (3 H, m), 1.09 (6 H, d, J=6.4 Hz).

Provenance & Evidence