2-Acetoxyisobutyroyl chloride → 3-(2-Acetoxyisobutyrylamino)-6-chloro-2-(4-chloropyridine-2-carbonyl)indole

HRID 379867Notes

Reaction equation

HRID 379867 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][N:15]=1)=[O:13].[C:21]([O:24][C:25]([CH3:30])([CH3:29])[C:26](Cl)=[O:27])(=[O:23])[CH3:22]>>[C:21]([O:24][C:25]([CH3:30])([CH3:29])[C:26]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][N:15]=1)=[O:13])=[O:27])(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 1234962-Acetoxyisobutyroyl chlorideHCID 183681263-Amino-6-chloro-2-(4-chloropyridine-2-carbonyl)indole

Product 1

HCID 183681673-(2-Acetoxyisobutyrylamino)-6-chloro-2-(4-chloropyridine-2-carbonyl)indole

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(4-chloropyridine-2-carbonyl)indole (Exampe 68) and 2-acetoxyisobutyryl chloride. m.p.: 228-229° C. (recrystallized from ethyl acetate) IR(KBr)ν: 3500, 3250, 1740, 1710, 1620, 1600, 1570, 1540, 1480, 1350, 1230, 1180, 1150, 740 cm−1.

Sources & evidence

ORD record
ord-6657160951914ec2b937eca9ad97ebdf
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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