2-Bromo-1-(pyrimidin-5-yl)ethan-1-one → HCID 18368109, compound

HRID 379873Notes

Reaction equation

HRID 379873 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.Br[CH2:17][C:18]([C:20]1[CH:21]=[N:22][CH:23]=[N:24][CH:25]=1)=[O:19]>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:17]=1[C:18]([C:20]1[CH:21]=[N:22][CH:23]=[N:24][CH:25]=1)=[O:19]

Participants

3

Reactant 2

HCID 155548942-Bromo-1-(pyrimidin-5-yl)ethan-1-oneHCID 183678884-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile

Product 1

HCID 18368109HCID 18368109, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 5-bromoacetylpyrimidine (step 1). 1H-NMR (CDCl3) δ: 9.29 (1 H, s), 9.03 (2 H, s), 8.02 (1 H, d, J=1.6 Hz), 7.57 (1 H, d, J=8.4 Hz), 7.35 (1 H, dd, J=1.6, 8.4 Hz), 6.13 (2 H, br s), 4.01 (2 H, q, J=7.1 Hz), 1.02 (3 H, t, J=7.1 Hz).

Sources & evidence

ORD record
ord-b51480f973b84e5883892322321fd47d
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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