Acetyl chloride → HCID 18367838, compound

HRID 379874Notes

Reaction equation

[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:3]=1[C:17]([C:19]1[CH:20]=[N:21][CH:22]=[N:23][CH:24]=1)=[O:18].[C:25](Cl)(=[O:27])[CH3:26]>>[C:25]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:3]=1[C:17]([C:19]1[CH:20]=[N:21][CH:22]=[N:23][CH:24]=1)=[O:18])(=[O:27])[CH3:26]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 18368109HCID 18368109, compound

Product 1

HCID 18367838HCID 18367838, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 2 (Method A) employing 3-amino-6-chloro-1-ethoxycarbonyl-2-(5-pyrimidinylcarbonyl)indole (step 2) and acetyl chloride.

Sources & evidence

ORD record: ord-ea3f4c2fb6c943a0a9fdd901e4455fcb
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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