Acetyl chloride → HCID 18367991, compound

HRID 379876Notes

Reaction equation

HRID 379876 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=1)=[O:13].[C:21](Cl)(=[O:23])[CH3:22]>>[C:21]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=1)=[O:13])(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 18367773HCID 18367773, compound

Product 1

HCID 18367991HCID 18367991, compound

Procedure

The title compound was prepared according to the procedure described in Example 19 from 3-amino-6-chloro-2-(3-methylpyridine-2-carbonyl)indole (Example 367) and acetyl chloride. m.p.: 173-175° C. (recrystallized from ethyl acetate)

Workup

  1. customm.p.: 173-175° C. (recrystallized from ethyl acetate)

Sources & evidence

ORD record
ord-95f60d3679ac471085c9ab868b280b31
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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