Isovaleryl chloride → HCID 18367951, compound

HRID 379877Notes

Reaction equation

[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=1)=[O:13].[C:21](Cl)(=[O:26])[CH2:22][CH:23]([CH3:25])[CH3:24]>>[Cl:11][C:7]1[CH:6]=[C:5]2[C:10]([C:2]([NH:1][C:21](=[O:26])[CH2:22][CH:23]([CH3:25])[CH3:24])=[C:3]([C:12]([C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=3)=[O:13])[NH:4]2)=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 66054Isovaleryl chloride

HCID 18367773HCID 18367773, compound

Product 1

HCID 18367951HCID 18367951, compound

Procedure

The title compound was prepared according to the procedure described in Example 19 from 3-amino-6-chloro-2-(3-methylpyridine-2-carbonyl)indole (Example 367) and isovaleryl chloride. m.p.: 142-144° C. (recrystallized from ethyl acetate)

Workup

customm.p.: 142-144° C. (recrystallized from ethyl acetate)

Sources & evidence

ORD record: ord-9e57b61ac9ae4f859e23e731ced6fbcc
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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