4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile → 3-Amino-6-chloro-1-ethoxycarbonyl-2-[4-[(tert-butyldimethylsilyloxy)methyl]pyridine-2-carbonyl]indole
Reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.Br[CH2:17][C:18]([C:20]1[CH:25]=[C:24]([CH2:26][O:27][Si:28]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29])[CH:23]=[CH:22][N:21]=1)=[O:19]>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:17]=1[C:18]([C:20]1[CH:25]=[C:24]([CH2:26][O:27][Si:28]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29])[CH:23]=[CH:22][N:21]=1)=[O:19]Participants
3
Procedure
The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromoacetyl-4-[(tert-butyldimethylsilyloxy)methyl]pyridine (step 4).
Sources & evidence
- ORD record
- ord-ce5ce6908f0044ecb32540ba859e7390
- Source dataset
- uspto-grants-2001_10
- Patent number
- US06300363B1
Reaction notes
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