Acetyl chloride → 3-Acetylamino-6-chloro-2-[4-[(tert-butyldimethylsilyloxy)methyl]pyridine-2-carbonyl]indole
Reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4](C(OCC)=O)[C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([CH2:25][O:26][Si:27]([C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:29])[CH3:28])[CH:22]=[CH:21][N:20]=1)=[O:18].[C:34](Cl)(=[O:36])[CH3:35]>>[C:34]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([CH2:25][O:26][Si:27]([C:30]([CH3:32])([CH3:33])[CH3:31])([CH3:29])[CH3:28])[CH:22]=[CH:21][N:20]=1)=[O:18])(=[O:36])[CH3:35]Participants
3
Procedure
The title compound was prepared according to the procedure described in step 1 of Example 2 (Method A) from 3-amino-6-chloro-1-ethoxycarbonyl-2-[4-[(tert-butyldimethylsilyloxy)methyl]pyridine-2-carbonyl]indole (step 5) and acetyl chloride.
Sources & evidence
- ORD record
- ord-2c04f3aa98a8440da9a1a707ce1005fc
- Source dataset
- uspto-grants-2001_10
- Patent number
- US06300363B1
Reaction notes
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