Isovaleryl chloride → 2-(4-Acetoxymethyl-2-furoyl)-6-chloro-1-ethoxycarbonyl-3-(isovalerylamino)indole

HRID 379889Notes

Reaction equation

HRID 379889 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH:7]=[C:8]([C:11]([C:13]2[N:14]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:15]3[C:20]([C:21]=2[NH2:22])=[CH:19][CH:18]=[C:17]([Cl:23])[CH:16]=3)=[O:12])[O:9][CH:10]=1)(=[O:3])[CH3:2].[C:29](Cl)(=[O:34])[CH2:30][CH:31]([CH3:33])[CH3:32]>>[C:1]([O:4][CH2:5][C:6]1[CH:7]=[C:8]([C:11]([C:13]2[N:14]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:15]3[C:20]([C:21]=2[NH:22][C:29](=[O:34])[CH2:30][CH:31]([CH3:33])[CH3:32])=[CH:19][CH:18]=[C:17]([Cl:23])[CH:16]=3)=[O:12])[O:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 66054Isovaleryl chlorideHCID 183679072-(4-Acetoxymethyl-2-furoyl)-3-amino-6-chloro-1-(ethoxycarbonyl)indole

Product 1

HCID 183679002-(4-Acetoxymethyl-2-furoyl)-6-chloro-1-ethoxycarbonyl-3-(isovalerylamino)indole

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 2 (Method A) employing 2-(4-acetoxymethyl-2-furoyl)-3-amino-6-chloro-1-(ethoxycarbonyl)indole (step 2) and isovaleryl chloride.

Sources & evidence

ORD record
ord-dbc6864493a94280ab1cbe4b73f6b6ae
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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