Propionyl chloride → 2-(4-Acetoxymethyl-2-furoyl)-6-chloro-1-ethoxycarbonyl-3-(propionylamino)indole

HRID 379891Notes

Reaction equation

HRID 379891 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH:7]=[C:8]([C:11]([C:13]2[N:14]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:15]3[C:20]([C:21]=2[NH2:22])=[CH:19][CH:18]=[C:17]([Cl:23])[CH:16]=3)=[O:12])[O:9][CH:10]=1)(=[O:3])[CH3:2].[C:29](Cl)(=[O:32])[CH2:30][CH3:31]>>[C:1]([O:4][CH2:5][C:6]1[CH:7]=[C:8]([C:11]([C:13]2[N:14]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:15]3[C:20]([C:21]=2[NH:22][C:29](=[O:32])[CH2:30][CH3:31])=[CH:19][CH:18]=[C:17]([Cl:23])[CH:16]=3)=[O:12])[O:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 183679072-(4-Acetoxymethyl-2-furoyl)-3-amino-6-chloro-1-(ethoxycarbonyl)indole

Product 1

HCID 183677572-(4-Acetoxymethyl-2-furoyl)-6-chloro-1-ethoxycarbonyl-3-(propionylamino)indole

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 2 (Method A) employing 2-(4-acetoxymethyl-2-furoyl)-3-amino-6-chloro-1-(ethoxycarbonyl)indole (Exampe 373, step 2) and propionyl chloride.

Sources & evidence

ORD record
ord-7cd0cdfb5c50412b9d968d9a556c2521
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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