4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile → HCID 18367778, compound

HRID 379907Notes

Reaction equation

HRID 379907 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.Br[CH2:17][C:18]([C:20]1[C:25]([CH2:26][O:27][Si:28]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29])=[CH:24][CH:23]=[CH:22][N:21]=1)=[O:19]>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:17]=1[C:18]([C:20]1[C:25]([CH2:26][O:27][Si:28]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29])=[CH:24][CH:23]=[CH:22][N:21]=1)=[O:19]

Participants

3

Reactant 2

HCID 183678884-Chloro-2-[(ethoxycarbonyl)amino]benzonitrileHCID 18368144HCID 18368144, compound

Product 1

HCID 18367778HCID 18367778, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 1 employing 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromoacetyl-3-(tert-butyldimethylsilyloxymethyl)pyridine (step 2).

Sources & evidence

ORD record
ord-971cc3380b9a472fa917e8214ddd1bfe
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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