(2E,4E)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienal → HCID 178460849, compound

HRID 379925Notes

Reaction equation

HRID 379925 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:25])([C:16]([S:19][CH:20]([CH2:23][OH:24])[CH2:21][OH:22])([CH3:18])[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[F:26][C:27]([F:41])([F:40])[C:28]1[CH:33]=[CH:32][C:31](/[CH:34]=[CH:35]/[CH:36]=[CH:37]/[CH:38]=O)=[CH:30][CH:29]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:25])([C:16]([CH3:18])([S:19][C@@H:20]1[CH2:23][O:24][C@@H:38](/[CH:37]=[CH:36]/[CH:35]=[CH:34]/[C:31]2[CH:30]=[CH:29][C:28]([C:27]([F:26])([F:40])[F:41])=[CH:33][CH:32]=2)[O:22][CH2:21]1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 10609261(2E,4E)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienalHCID 18363338(RS)-2-(2,4-difluorophenyl)-3-[(1,3-dihydroxy-2-propyl)thio]-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Product 1

HCID 178460849HCID 178460849, compound

Procedure

Reaction was carried out in the same manner as in Example 4 using (RS)-2-(2,4-difluorophenyl)-3-[(1,3-dihydroxy-2-propyl)thio]-3-methyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol and (2E,4E)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienal as described in Reference example 25 to obtain the title compound, a major product as a colorless foam.

Workup

  1. customReaction

Sources & evidence

ORD record
ord-f2caf725706f487e97ef674404c3c22f
Source dataset
uspto-grants-2001_10
Patent number
US06300357B1

Reaction notes

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