反应详情

In 30 ml of methylene chloride were dissolved 2.15 g of trans-4-(trifluoromethyl)cinnamyl alcohol, and 14 g of active manganese dioxide were added to the solution at 0° C., followed by stirring of the resulting mixture for 15 minutes and then stirring at room temperature for 2 hours. The solid was removed by filtration and the filtrate was concentrated to obtain a crystalline residue. The residue was recrystallized from a mixed solvent of benzene-hexane to obtain the title compound having a melting point of 60 to 61° C. in a yield of 90%.

1. additionwere added to the solution at 0° C.
2. stirringstirring at room temperature for 2 hours
3. customThe solid was removed by filtration
4. concentrationthe filtrate was concentrated
5. customto obtain a crystalline residue
6. customThe residue was recrystallized from a mixed solvent of benzene-hexane