HCID 24727994, compound → (3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)pyrrolidine

Participants

Reaction Steps

A mixture of (3R,4R)-1-benzyl-3,4-bis(tert-butyldimethylsilyloxy)pyrrolidine (13.4 g, 31.8 mmol) and Pd(OH)2/C (2.23 g, 3.18 mmol, 20%) in MeOH (134 mL) was stirred for 20 h under H2 atmosphere (balloon). The reaction mixture was filtered through a Celite plug and concentrated under reduced pressure to afford 10.5 g (91%) of the crude (3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)pyrrolidine that was used directly without further purification.

Provenance & Evidence