Sodium Hydroxide → HCID 54094447, compound

Participants

Reaction Steps

Lithium aluminium hydride (86.67 ml, 1.0 M solution in tetrahydrofuran) was added dropwise to a stirred solution of (2R)-2-(biphenyl-4-yloxy)propanoic acid, ethyl ester (11.79 g, Example 1a) in dry tetrahydrofuran (200 ml) at 0° C. The resulting solution was stirred at room temperature under nitrogen for 3 hours. Water (3.3 ml), then aqueous sodium hydroxide (50% solution, 3.3 ml) then water (9.9 ml) were cautiously added to the solution at 0° C. Diethyl ether (200 ml) and anhydrous magnesium sulfate (20 g) were added and the solution stirred at room temperature for 20 minutes. The solution was filtered and the filtrate concentrated under reduced pressure to give the sub-title compound as a solid (9.43 g).

Provenance & Evidence