4-Hydroxybiphenyl → (2S)-2-(Biphenyl-4-yloxy)propanoic acid, ethyl ester

Participants

Reaction Steps

Prepared according to the method described in Example 1a) from diethylazodicarboxylate (6.74 ml), triphenylphosphine (13.11 g), (R)-(+)-ethyl lactate (5.67 ml) and 4-phenylphenol (8.51 g) in dry tetrahydrofuran (125 ml). The residue obtained after work-up was purified by column chromatography over silica eluting with isohexane:dichloromethane (2:3) to give the sub-title compound as an oil (11.3 g).

Provenance & Evidence