Sodium Carbonate → HCID 57044961, compound

Participants

Reaction Conditions

Reaction Steps

Prepared according to the method described in Example 12b) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.30 g, Example 33), 4-bromophenylsulfonic acid amide (0.26 g), ethanol (6 ml), 2M aqueous sodium carbonate (1.0 ml) and tetrakis(triphenylphosphine)palladium (0) (0.03 g) with heating at 90° C. for 6 hours. After work-up, the residue was purified by column chromatography on silica gel eluting with 5:95 methanol:ethyl acetate to give the title compound as a solid (0.04 g).

Provenance & Evidence