Sodium Carbonate → HCID 59970507, compound

Participants

Reaction Steps

Prepared according to the method described in Example 12b) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.15 g, Example 33), 4-bromo-3-methyl-N-(2-pyrrolidin-1-yl-ethyl)benzamide (0.31 g, Example 63a)), 2M aqueous sodium carbonate (0.57 ml) and tetrakis(triphenylphosphine)palladium(0) (0.012 g) in ethanol(5 ml) with heating at reflux for 4 hours. After work up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-10% ethanol in dichloromethane to give the title compound as an oil. (0.14 g).

Provenance & Evidence