HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-Bromo-2-methylbenzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfur Dioxide | HCID 1119 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Benzenamine, 3-bromo-4-methyl- | HCID 82187 | — |
| Reactant | Magnesium Chloride | HCID 5360315 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Catalyst | Cupric Chloride | HCID 24014 | — |
| Product | 4-Bromo-2-methylbenzene-1-sulfonamide | HCID 20616767 | — |
Reaction Steps
Prepared by the method of Example 69a) using 3-bromo-4-methylaniline (2.60 g, Example 78a)), sodium nitrite (1.05 g), concentrated hydrochloric acid (20 ml), anhydrous magnesium chloride (2.6 g), acetic acid saturated with sulfur dioxide (50 ml) and copper (II) chloride (0.37 g). The normal work-up and subsequent treatment with ammonium hydroxide (50 ml) followed by the same work-up afforded the subtitle compound as a solid (1.51 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300352B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-6eed423eaf45419abf435b98bb927e2c |
| Source note | uspto-grants-2001_10 |