Sulfuric Acid → 5-bromo-2-fluorobenzamide

HRID 380047Notes

Reaction equation

HRID 380047 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[C:7]#[N:8].S(=O)(=O)(O)[OH:12]>>[F:10][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:9][C:6]=1[C:7]([NH2:8])=[O:12]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 27249005-Bromo-2-fluorobenzonitrile

Product 1

HCID 27789015-bromo-2-fluorobenzamide

Procedure

5-Bromo-2-fluorobenzonitrile (0.370 g) was heated at 110° C. for 1 hour in concentrated sulfuric acid (10 ml). After cooling, the reaction was diluted with ice-cold water and the slurry was extracted into ethyl acetate, dried over anhydrous magnesium sulfate, filtered and evaporated to afford the sub-title compound as a solid (0.328 g).

Workup

  1. temperatureAfter cooling
  2. additionthe reaction was diluted with ice-cold water
  3. extractionthe slurry was extracted into ethyl acetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-05e4d315ff034bdb8df2b36a7570b13d
Source dataset
uspto-grants-2001_10
Patent number
US06300352B1

Reaction notes

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