反应详情

Prepared according to the method described in Example 1d) from (3RS,4S)-4-(4-bromophenoxy)-1-pyridin-3-yl-hex-1-yn-3-ol (3.42 g, Example 87c)) and 5% rhodium on carbon (0.5 g) in ethyl acetate (100 ml). After work up crude material was purified by flash column chromatography over silica eluting with ethyl acetate to give a mixture of diastereomers. The mixture was separated by normal-phase HPLC eluting with 2% propan-2-ol in dichloromethane to give the sub-title compound as the second eluting, major diastereomer (2 g).

1. customPrepared
2. customAfter work up crude material was purified by flash column chromatography over silica eluting with ethyl acetate
3. customto give
4. additiona mixture of diastereomers
5. customThe mixture was separated by normal-phase
6. washHPLC eluting with 2% propan-2-ol in dichloromethane