Sodium Carbonate → (1S,2R)-4'-[1-Ethyl-2-hydroxy-4-pyridin-3-yl-butoxyl]-4-fluorobiphenyl-3-sulfonic acid amide

Participants

Reaction Conditions

Reaction Steps

Prepared according to the method described in Example 12b) from from (3R,4S)-3-[4-(4-Bromophenoxy)-3-(t-butyldimethylsilanyloxy)hexyl]pyridine (0.20 g, Example 88b)), 2-fluoro-5-bromophenylsulfonamide (0.177 g, Example 35a)), 2M aqueous sodium carbonate (0.54 ml) and tetrakis(triphenylphosphine)palladium (0) (0.014 g) in ethanol (3 ml) with heating at 90 ° C. for 4 hours. The residue was purified by column chromatography over silica eluting with ethyl acetate to give the title compound as a foam (0.14 g).

Provenance & Evidence