HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 18368972, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | tert-Butyl (((1,1-dimethylethoxy)carbonyl)oxy)carbamate | HCID 2728863 | — |
| Reactant | 3-[(4-methoxyphenyl)thio]propanoic acid | HCID 4431444 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18368972 | HCID 18368972 | 98.8% |
Reaction Steps
To a solution of the compound prepared in Example 8(11) (106 mg) in DMF (5 ml), N-t-butoxycarbonyl-N-t-butoxycarbonyloxyamine (120 mg), EDC hydrochloride (106 mg) and 4-(dimethylamino)pyridine (6 mg) were added at 0° C. The mixture was stirred for 16 hours at room temperature. To the reaction solution, water was added and it was extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of ammonium chloride, a saturated aqueous solution of sodium bicarbonate, a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the title compound (211 mg) having the following physical data.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300514B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-37bb883492d04fef89c216655ba7c61f |
| Source note | uspto-grants-2001_10 |