HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R)-N-benzyloxycarbonyl-4-hydroxy-1-(4,5-diphenyloxazol-2-yl)butylamine → (1R)-4-hydroxy-1-(4,5-diphenyloxazol-2-yl)butylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R)-N-benzyloxycarbonyl-4-hydroxy-1-(4,5-diphenyloxazol-2-yl)butylamine | HCID 53739918 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1R)-4-hydroxy-1-(4,5-diphenyloxazol-2-yl)butylamine | HCID 54014820 | 69.4% |
Reaction Steps
A mixture of (1R)-N-benzyloxycarbonyl-4-hydroxy-1-(4,5-diphenyloxazol-2-yl)butylamine (12 g) and 10% Pd/C (2 g) in methanol (20 ml) was stirred under H2 for 5 hours. The catalyst was filtered off and filtrate was evaporated. The residue was recrystallized with ether to give (1R)-4-hydroxy-1-(4,5-diphenyloxazol-2-yl)butylamine (5.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300344B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-d641993e0d1941a68770749a9df00e22 |
| Source note | uspto-grants-2001_10 |