HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-{Hydroxy-(3-methoxyphenyl)methyl}cyclooctanone → 2-(3-Methoxybenzyl)cyclooctanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-{Hydroxy-(3-methoxyphenyl)methyl}cyclooctanone | HCID 18367257 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(3-Methoxybenzyl)cyclooctanone | HCID 18367411 | 42.6% |
Reaction Steps
A mixture of 2-{hydroxy-(3-methoxyphenyl)methyl}-cyclooctanone (6.0 g) and 10% Pd/C (2 g) in ethanol (120 ml) was stirred under H2 for 10 hours. The catalyst was filtered off and filtrate was evaporated in vacuo. The residue was purified by chromatography on silica gel to give 2-(3-methoxybenzyl)cyclooctanone (2.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300344B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-359dd7f4185c4e369354f119f50008ca |
| Source note | uspto-grants-2001_10 |