1-(3-Benzyloxybenzoyl)-2-(4,5-diphenyl-2-oxazolyl)piperidine → 1-(3-Hydroxybenzoyl)-2-(4,5-diphenyl-2-oxazolyl)piperidine

Participants

Reaction Steps

A mixture of 1-(3-benzyloxybenzoyl)-2-(4,5-diphenyl-2-oxazolyl)piperidine (95 mg) and 10% Pd—C (50% wet, 15 mg) in ethyl acetate (3 ml)—10% methanolic hydrogen chloride was stirred in the presence of atmospheric H2 gas at room temperature for 7 hours and filtered. The filtrate was evaporated in vacuo to afford 1-(3-hydroxybenzoyl)-2-(4,5-diphenyl-2-oxazolyl)piperidine (100 mg) as a crude oil.

Provenance & Evidence