Hydrochloric Acid → HCID 178514085, compound

Participants

Reaction Steps

To a solution of the ester from Step 1 (1.9 g, 3.5 mmol) in THF:methanol (10 mL each) and water (2 mL) was added sodium hydroxide (0.4 g, 10 mmol), and the solution was stirred overnight at room temperature. The solution was added to 1N HCl:ethyl acetate (30 mL each). The organic layer was separated and washed with 1N HC1, brine, dried over MgSO4, and concentrated. The product was obtained as a white foam (0.53 g, 53%); ES-MS 289 (m+1).

Provenance & Evidence