HRID38019

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC1=Nc2cc(Br)ccc2C=C(C(=O)O)C1

HCID66959623

未命名化合物

HCID86653472

未命名化合物

PRODUCTS

生成物

结构：CCCN(CCCO[Si](C)(C)C(C)(C)C)C(=O)C1=Cc2ccc(Br)cc2N=C(NC(=O)OC(C)(C)C)C1

HCID86652684

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by the procedure as described in Example 101 (Step H) using (1E,4E)-8-bromo-2-(tert-butoxycarbonylamino)-3H-benzo[b]azepine-4-carboxylic acid and 3-(tert-butyldimethylsilyloxy)-N-propylpropan-1-amine. MS APCI (+) m/z 594, 596 (M+1, Br pattern) detected.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d3063404fdce45e0b52aa0425b58f71f
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08524702B2
来源说明: uspto-grants-2013_09

反应 SMILES

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2=[C:6]([CH:23]=1)[N:7]=[C:8]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:9][C:10]([C:12]([OH:14])=O)=[CH:11]2.[Si:24]([O:31][CH2:32][CH2:33][CH2:34][NH:35][CH2:36][CH2:37][CH3:38])([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2=[C:6]([CH:23]=1)[N:7]=[C:8]([NH:15][C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:22])[CH3:21])[CH2:9][C:10]([C:12](=[O:14])[N:35]([CH2:34][CH2:33][CH2:32][O:31][Si:24]([C:27]([CH3:28])([CH3:30])[CH3:29])([CH3:26])[CH3:25])[CH2:36][CH2:37][CH3:38])=[CH:11]2