Sulfuric Acid → HCID 178455987, compound

Participants

Role	Name	HCID	Charge
Reactant	Sulfuric Acid	HCID 1118	—
Reactant	2,5,6,10,13-Pentaazatetradecanedioic acid, 12-(1,1-dimethylethyl)-8-hydroxy-6-((4-(2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl)phenyl)methyl)-3-(1-methylpropyl)-4,11-dioxo-9-(phenylmethyl)-, dimethyl ester,(3S-(3R(R),8R,9R,12R*))-	HCID 467973	—
Product	HCID 178455987	HCID 178455987	—

Reaction Steps

35 ml of an 80% aqueous H2SO4 solution are added to 354 mg (0.435 mmol) of 1-{4-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-phenyl}-4(S)-hydroxy-2-N-(N-methoxycarbonyl-(L)-iso-leucyl)amino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane, with ice-cooling. After stirring for 75 min, the mixture is worked up analogously to Example 26 to yield the title compound: HPLC20-100: tRet=12.6; FAB MS (M+H)+=696.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06300519B1
Source dataset	uspto-grants-2001_10
ORD ID	ord-f0f288f7bc5947a88189b22c442a4dfd
Source note	uspto-grants-2001_10