Hydrochloric Acid → HCID 66578105, compound

Participants

Reaction Steps

Analogously to Example 40g, 40 ml of 4M HCl in dioxane are added to 1.9 g (3 mmol) of 1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-2-N-Boc-amino-5(S)-N-(N-methoxycarbonyl-(L)-iso-leucyl)amino-6-phenyl-2-azahexane and the mixture is diluted with 3 ml of DMF. After 2.5 hours, the mixture is worked up. The title compound is obtained: TLC: Rf=0.55 (methylene chloride/methanol: 9/1); HPLC20-100: tRet=8.74; FAB MS (M+H)+=534.

Provenance & Evidence