Sodium borohydride → HCID 18364412, compound

Participants

Reaction Steps

26 mmol of NaBH4 are added at ambient temperature to a solution of 24 mmol of the compound obtained in Step E of Example 1 in 100 ml of methanol. After reacting for 2 hours, one equivalent of NaBH4 is added to the reaction mixture. After reacting for 12 hours, the solution is concentrated and then diluted with ethyl acetate, washed with 1N HCl solution, then with water and then with saturated NaCl solution, subsequently dried over calcium sulphate, filtered and concentrated under reduced pressure. Chromatography over silica gel (dichloromethane/ethyl acetate: 95/5) allows the expected product to be isolated.

Provenance & Evidence