化工社化工社 化学情報印刷レポート · 研究参考用
Methyl iodide → 4-Ethynyl-4-methoxy-4'-propylbicyclohexyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 4-Ethynyl-4'-propylbicyclohexyl-4-ol | HCID 18364504 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 4-Ethynyl-4-methoxy-4'-propylbicyclohexyl | HCID 18364508 | — |
反応手順
28.85 ml of a 15% solution of butyllithium in hexane are added dropwise to a solution, cooled to −30° C., of 13.0 g of 4-ethynyl-4′-propylbicyclohexyl-4-ol in 24 ml of THF. A solution of 4.67 ml of iodomethane in 36 ml of dimethyl sulfoxide is subsequently added dropwise to the reaction mixture at −5° C. The mixture is stirred at RT overnight and subjected to conventional work-up, giving 4-ethynyl-4-methoxy-4′-propylbicyclohexyl (C 45 I, Δε−3.72, Δn−0.022).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06303194B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-7131e57670c74619b1ae23989b89305b |
| 出典メモ | uspto-grants-2001_10 |