2-(Chloromethyl)quinoline → HCID 11349715, compound

Participants

Reaction Steps

Using the procedure described in Example 23 starting from 2-chloromethyiquinoline and methyl 2-(3-hydroxyphenylsulfanyl)benzoate, methyl ester of the title acid was obtained as red-brown crystals in nearly quantitative yield, m.p. 52-55° C. An analytical sample was further purified by crystallization from a mixture of ethanol and ether. For C24H19NO3S (401.5) calculated: 71.80% C, 4.77% H, 3.49% N, 7.99% S; found: 71.83% C, 4.76% H, 3.18% N, 7.75% S.

Provenance & Evidence