HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenyethanol → Methyl 3-Fluoro-4{N-[2(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenylethyl]-N-methylamino}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenyethanol | HCID 15520998 | — |
| Reactant | 2-(3-(S)-methoxymethoxypyrrolidin-1-y)-2-(R)-phenylethanol | HCID 15520999 | — |
| Reactant | Methyl 3-fluoro-4-(methylamino)benzoate | HCID 18359028 | — |
| Product | Methyl 3-Fluoro-4{N-[2(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenylethyl]-N-methylamino}benzoate | HCID 69951846 | 52% |
Reaction Steps
This was prepared from 2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-1-(S)-phenylethanol and 2-(3-(S)-methoxymethoxypyrrolidin-1-yl)-2-(R)-phenylethanol and methyl 3-fluoro-4-methylaminobenzoate in 52% yield according to the procedures similar to those described in Example 29 (i).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06303602B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-9ecd0cdffa66441aae4fd724ebe788f3 |
| Source note | uspto-grants-2001_10 |