Acrylonitrile → HCID 18677418, compound

Participants

Reaction Steps

A mixture of 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indole (0.07mol), acrylonitrile (0.14 mol) and Aliquat 336 (3 drops) in 2-propanol (150 ml) was stirred and refluxed for 30 minutes. The reaction mixture was cooled on an ice-bath and the resulting precipitate was filtered off, washed with diisopropyl ether (50 ml) and dried, yielding 14.5 g (87%) of 1,3,4,5-tetrahydro-5-methyl-2H-pyrido[4,3-b]indole-2-propanenitrile (intermediate 15).

Provenance & Evidence