Hydrazine → HCID 178487565, 화합물

HRID 380437노트

반응식

HRID 380437 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:5]=1F)=O.[NH2:13][NH2:14]>O>[CH3:11][O:10][C:7]1[CH:6]=[C:5]2[C:4]([C:2]([CH3:1])=[N:13][NH:14]2)=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 5928212'-Fluoro-4'-methoxyacetophenone

생성물 1

HCID 178487565HCID 178487565, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-fluoro-4-methoxyacetophenone (5.0 g) was treated with hydrazine (75 ml) under argon and the mixture was heated to reflux for 12 hours. After cooling to room temperature, the reaction mixture was poured into water (200 ml) then extracted three times with ethyl acetate (50 ml). The combined extracts were dried over sodium sulphate then evaporated. The residue was subjected to flash chromatography on silica eluting with a mixture of ethyl acetate and hexane (1:3, v/v) to yield the title compound (4.05 g).

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 12 hours
  3. extractionthen extracted three times with ethyl acetate (50 ml)
  4. dry with materialThe combined extracts were dried over sodium sulphate
  5. customthen evaporated
  6. additionThe residue was subjected to flash chromatography on silica eluting with a mixture of ethyl acetate and hexane (1:3

출처 및 근거

ORD 기록
ord-7e55a2d6763e428eb20b6a22c94fa28e
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06303600B1

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