Methyl 3-iodo-4-(3-methyl-but-2-enylamino)-benzoate → Methyl 3-(propan-2-yl)-1H-indole-5-carboxylate

Participants

Reaction Conditions

Reaction Steps

A solution of methyl 3-iodo-4-(3-methyl-but-2-enylamino)-benzoate (2.0 g, Reference Example 53) in triethylamine (1.6 ml) and acetonitrile (35 ml) was treated with palladium acetate (0.05 g). The mixture was sealed in a bomb and heated at 110° C. for 18 hours. After cooling the reaction mixture was filtered and the filtrate was evaporated. The residue was subjected to flash chromatography on silica eluting with a mixture of ethyl acetate and petroleum ether (1:4, v/v) to give the title compound (1.0 g).

Provenance & Evidence