Pyridine, 1,2,3,6-tetrahydro-4-[4-(trifluoromethyl)phenyl]- → 4-(4-(Trifluoromethyl)phenyl)piperidine

Participants

Reaction Steps

A mixture of 0.54 g (1.22 mmol) of 4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine and 0.1 g of 10% Pd/C in 20 mL of MeOH was stirred under a hydrogen atmosphere at 45 psi for 4 h. The reaction mixture was filtered through a thin pad of celite eluting with CH2Cl2. The solution was concentrated to give 0.26 g of the title compound.

Provenance & Evidence