1-Benzyl-4-(3-phenylpropyl)piperidin-4-ol → 4-(3-Phenylpropyl)piperidin-4-ol

Participants

Reaction Steps

A mixture of 3.3 g (10.7 mmol) of 1-benzyl-4-hydroxy-4-(3-phenylpropyl)piperidine and 0.5 g of Pd(OH)2 (Pearlman's catalyst) in 80 mL of MeOH was hydrogenated at 50 psi for 24 h. The reaction mixture was filtered through a thin pad of celite and concentrated to give the title compound.

Provenance & Evidence