Sodium Bicarbonate → HCID 57082681, compound

Participants

Reaction Steps

To a solution of 1.47 g (3.71 mmol) of 1-(2,2,2-trichloroethoxycarbonyl)-4-(2-(phenylmercapto)ethyl)piperidine in 20 mL of glacial acetic acid was heated at 40° C. To this solution was added portionwise 2 g of zinc powder over a period of 1 h with vigorous stirring. After 24 h at 40° C., the reaction mixture was cooled to rt and carefully poured into 250 mL of sat'd NaHCO3 solution. The mixture was extracted 5 times with CH2Cl2 and the combined organic fractions were washed with sat'd NaCl solution, and dried over MgSO4 and filtered. The filtrate was concentrated to give the title compound.

Provenance & Evidence