4-(4-Fluorophenyl)piperidine → HCID 20694312, compound

HRID 380518Notes

Reaction equation

HRID 380518 reaction equation
[CH2:1]([N:4]1[CH2:8][C@@H:7]([C:9]2[CH:13]=[CH:12][S:11][CH:10]=2)[C@H:6]([CH:14]=O)[CH2:5]1)[CH:2]=[CH2:3].[F:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1.C(N1C[C@@H](C2C=CSC=2)[C@H](C=O)C1)C1C=CC=CC=1>>[CH2:1]([N:4]1[CH2:8][C@@H:7]([C:9]2[CH:13]=[CH:12][S:11][CH:10]=2)[C@H:6]([CH2:14][N:26]2[CH2:27][CH2:28][CH:23]([C:20]3[CH:19]=[CH:18][C:17]([F:16])=[CH:22][CH:21]=3)[CH2:24][CH2:25]2)[CH2:5]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 27591364-(4-Fluorophenyl)piperidineHCID 20694314HCID 20694314, compound2×HCID 20694317HCID 20694317, compound

Product 1

HCID 20694312HCID 20694312, compound

Procedure

The title compound was prepared from 1-allyl-3-(S)-formyl-4-(R)-(3-thienyl)pyrrolidine and 4-(4-fluorophenyl)piperidine by according to procedures described in Example 241, Step 5 with the change that 1-Allyl-3-(S)-formyl-4-(R)-(3-thienyl)pyrrolidine replaced 1-benzyl-3-(S)-formyl-4-(R)-(3-thienyl)pyrrolidine. 1H NMR (CDCl3) is consistent with structure.

Sources & evidence

ORD record
ord-97aadda6cc48419496c6818f83901dc4
Source dataset
uspto-grants-2001_10
Patent number
US06303593B1

Reaction notes

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