Hydrochloric Acid → Imidazo[1,2-a]pyridine-7-carboxylic acid

HRID 380523ノート

反応式

HRID 380523 の反応式
C([O:8][C:9]([C:11]1[CH:16]=[CH:15][N:14]2[CH:17]=[CH:18][N:19]=[C:13]2[CH:12]=1)=[O:10])C1C=CC=CC=1.[OH-].[K+].Cl>CO>[N:19]1[CH:18]=[CH:17][N:14]2[CH:15]=[CH:16][C:11]([C:9]([OH:10])=[O:8])=[CH:12][C:13]=12

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 54461037Benzyl-imidazo[1,2-a]pyridine-7-carboxylate

生成物 1

HCID 18364844Imidazo[1,2-a]pyridine-7-carboxylic acid収率 97.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 0.16 g (0.634 mmol) of benzyl-imidazo[1,2-a]pyridine-7-carboxylate and 1.5 mL of a 1M aqueous solution of KOH (1.6 mmol) in 4 mL of CH3OH was stirred at rt for 2 h. The reaction mixture was made acidic with 1N HCl and partitioned between water and CH2Cl2. The organic fraction was dried over MgSO4 filtered and the filtrate was concentrated to give 0.1 g of the title compound.

後処理

  1. custompartitioned between water and CH2Cl2
  2. dry with materialThe organic fraction was dried over MgSO4
  3. filtrationfiltered
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-cb1a09e9073d4585857c6f40dc08963d
出典データセット
uspto-grants-2001_10
特許番号
US06303593B1

反応ノート

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