Hydrochloric Acid → Imidazo[1,2-a]pyridine-7-carboxylic acid

HRID 380523노트

반응식

HRID 380523 반응식
C([O:8][C:9]([C:11]1[CH:16]=[CH:15][N:14]2[CH:17]=[CH:18][N:19]=[C:13]2[CH:12]=1)=[O:10])C1C=CC=CC=1.[OH-].[K+].Cl>CO>[N:19]1[CH:18]=[CH:17][N:14]2[CH:15]=[CH:16][C:11]([C:9]([OH:10])=[O:8])=[CH:12][C:13]=12

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 54461037Benzyl-imidazo[1,2-a]pyridine-7-carboxylate

생성물 1

HCID 18364844Imidazo[1,2-a]pyridine-7-carboxylic acid수율 97.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 0.16 g (0.634 mmol) of benzyl-imidazo[1,2-a]pyridine-7-carboxylate and 1.5 mL of a 1M aqueous solution of KOH (1.6 mmol) in 4 mL of CH3OH was stirred at rt for 2 h. The reaction mixture was made acidic with 1N HCl and partitioned between water and CH2Cl2. The organic fraction was dried over MgSO4 filtered and the filtrate was concentrated to give 0.1 g of the title compound.

후처리

  1. custompartitioned between water and CH2Cl2
  2. dry with materialThe organic fraction was dried over MgSO4
  3. filtrationfiltered
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-cb1a09e9073d4585857c6f40dc08963d
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06303593B1

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