HCID 20694310, compound → HCID 20694280, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.1107 g (0.16 mmol) of 1-(2,4-dichlorobenzyl)-3-(S)-(4-(3-phenyl-2-((S)-2-phenylpropionyl)oxypropyl)piperidinylmethyl)-4-(S)-(3-thienyl)pyrrolidine (isomer 1) in 2 ml of THF at 0° C. was added 0.5 mL (0.5 mmol) of a 1 M solution of LiAlH4 in THF. The solution was stirred at 0° C. for 1 h, then was quenched by addition of 0.5 mL of 5N NaOH solution. The mixture was diluted with ethyl acetate, dried over MgSO4, filtered and the filtrate concentrated. The residue was purified by chromatography (silica, hexanes:acetone, 4:1) to give the title compound. Mass Spectrum (ESI) m/e=543 (M+1 35Cl, 35Cl), 545 (M+1 35Cl, 37Cl), and 547 (M+1 37Cl, 37Cl). [α]D=+11.7 (c=1.54, CHCl3).

Provenance & Evidence