HCID 20694310, compound → HCID 20694280, compound

HRID 380535Notes

Reaction equation

HRID 380535 reaction equation
[Cl:1][C:2]1[CH:45]=[C:44]([Cl:46])[CH:43]=[CH:42][C:3]=1[CH2:4][N:5]1[CH2:9][C@H:8]([C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[C@@H:7]([CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([CH2:22][CH:23]([O:31]C(=O)[C@H](C3C=CC=CC=3)C)[CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:18][CH2:17]2)[CH2:6]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:45]=[C:44]([Cl:46])[CH:43]=[CH:42][C:3]=1[CH2:4][N:5]1[CH2:9][C@H:8]([C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[C@@H:7]([CH2:15][N:16]2[CH2:17][CH2:18][CH:19]([CH2:22][CH:23]([OH:31])[CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:20][CH2:21]2)[CH2:6]1

Participants

3

Reactant 1

HCID 20694310HCID 20694310, compound

Product 1

HCID 20694280HCID 20694280, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from 1-(2,4-dichlorobenzyl)-3-(S)-(4-(3-phenyl-2-((S)-2-phenylpropionyl)oxypropyl)piperidinylmethyl)-4-(S)-(3-thienyl)pyrrolidine (isomer 2) according to procedures described in Step 2a. Mass Spectrum (ESI) m/e=543 (M+1 35Cl, 35Cl), 545 (M+1 35Cl, 37Cl), and 547 (M+1 37Cl, 37Cl). [α]D=+16.0 (c=2.0, CHCl3).

Sources & evidence

ORD record
ord-d9811483e94f4e2c861f13986f740fbe
Source dataset
uspto-grants-2001_10
Patent number
US06303593B1

Reaction notes

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