HCID 18365265, compound → HCID 17785787, compound

HRID 380549Notes

Reaction equation

HRID 380549 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19](OS(C(F)(F)F)(=O)=O)[CH:20]=3)[CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:32]([Mg]Br)=[CH2:33]>>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH:32]=[CH2:33])[CH:20]=3)[CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18365265HCID 18365265, compoundHCID 178418507HCID 178418507, compound

Product 1

HCID 17785787HCID 17785787, compoundYield 65%

Procedure

Beginning with 0.839 gm (1.9 mMol) 1-benzyl-4-(6-trifluoromethanesulfonyloxynaphth-2-yl)piperidine and 3.73 mL (3.7 mMol) vinylmagnesium bromide (1M in tetrahydrofuran), 0.394 gm (65%) of the desired compound were prepared as a waxy white solid substantially by the procedure of EXAMPLE 7.

Sources & evidence

ORD record
ord-8461c63e3a014c79a9d575c7a488ba63
Source dataset
uspto-grants-2001_10
Patent number
US06303627B1

Reaction notes

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