(Naphthalen-2-yl)boronic acid → HCID 18365291, compound

HRID 380551Notes

Reaction equation

HRID 380551 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1B(O)O.[O:14]([C:21]([N:23]1[CH2:28][CH:27]=[C:26](OS(C(F)(F)F)(=O)=O)[CH2:25][CH:24]1[CH2:37][CH3:38])=[O:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[O:14]([C:21]([N:23]1[CH2:28][CH:27]=[C:26]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)[CH2:25][CH:24]1[CH2:37][CH3:38])=[O:22])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 2734375(Naphthalen-2-yl)boronic acidHCID 18365282HCID 18365282, compound

Product 1

HCID 18365291HCID 18365291, compoundYield 75.3%

Procedure

Beginning with 3.62 gm (21.1 mMol) naphthalene-2-boronic acid and 5.70 gm (15.0 mMol) 1-phenoxycarbonyl-2-ethyl-4-trifluoromethanesulfonyloxy-1,2,3,6-tetrahydropyridine, 4.04 gm (75%) of the desired compound were prepared substantially as described in EXAMPLE 11.

Sources & evidence

ORD record
ord-559d4f209c15476c853aa4fa79fbaa46
Source dataset
uspto-grants-2001_10
Patent number
US06303627B1

Reaction notes

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