反应详情

To a solution of 5-acetylindan (500 mg, 3.1 mmol) in dichloromethane-methanol (2:1, 15 ml) was added tetrabutylammonium tribromide (1.64 g, 3.4 mmol) was added at room temperature. After 23 h, the mixture was concentrated and the residue was partitioned between diethyl ether (50 ml) and water (50 ml). The organic layer was separated and washed with water (50 ml), brine (50 ml), and dried (MgSO4). Removal of solvent gave 698 mg (56%) of the title compound as white solids.

1. additionwas added at room temperature
2. concentrationthe mixture was concentrated
3. customthe residue was partitioned between diethyl ether (50 ml) and water (50 ml)
4. customThe organic layer was separated
5. washwashed with water (50 ml), brine (50 ml)
6. dry with materialdried (MgSO4)
7. customRemoval of solvent