3-Bromoacetyl-5,6,7,8-tetrahydroisoquinoline → 7-Bromoacetyl-2-methyl-1,2,3,4-tetrahydroisoquinoline

HRID 380570Notes

Reaction equation

HRID 380570 reaction equation
[C:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][N:10]([CH3:14])[CH2:11]2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:15]CC(C1N=CC2CCCCC=2C=1)=O>>[Br:15][CH2:2][C:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][N:10]([CH3:14])[CH2:11]2)=[CH:6][CH:5]=1)=[O:3]

Participants

3

Reactant 2

HCID 154536983-Bromoacetyl-5,6,7,8-tetrahydroisoquinolineHCID 183653897-Acetyl-2-methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 154537147-Bromoacetyl-2-methyl-1,2,3,4-tetrahydroisoquinoline

Procedure

*7-bromoacetyl-2-methyl-1,2,3,4-tetrahydroisoquinoline was prepared from 7-acetyl-2-methyl-1,2,3,4-tetrahydroisoquinoline (P.Charpentier et al., Tetrahedron, 1996, 52, 10441) according to the procedure for preparing 3-bromoacetyl-5,6,7,8-tetrahydroisoquinoline described in Example 1.

Sources & evidence

ORD record
ord-e7a4f165e429497390f11f249969ccb1
Source dataset
uspto-grants-2001_10
Patent number
US06303628B1

Reaction notes

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