反应详情

To a slurry of sodium 4(4-fluorobenzyloxy)benzenesulfonate (0.5 grams, 1.64 mmole), in methylene chloride (5 mL) was added phosphorus pentachloride (275 mg, 1.31 mmole). The resulting mixture was heated at reflux for 7 hours. After cooling in an ice bath and quenching with water (15 mL), the mixture was extracted with ethyl acetate. The organic phase was washed brine, dried over sodium sulfate, and concentrated to afford 4-(4-fluorobenzyloxy)benzenesulfonyl chloride a white solid (130 mg, 26%).

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 7 hours
3. temperatureAfter cooling in an ice bath
4. customquenching with water (15 mL)
5. extractionthe mixture was extracted with ethyl acetate
6. washThe organic phase was washed brine
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated